Here are some basic VS2005 shortcut keys.
The one I use most is the comment code shortcut combo.
Alt+Space, N = Minimize current application
Alt+Space, X = Maximize current application
Alt+Space, R = Restore current application
Ctrl+K, Ctrl+C = Comment out the current selected section
Ctrl+K, Ctrl+U = Uncomment the current selected section
Shift+F7 = show designer window
F7 = show code window
Ctrl+Alt+A = Command Window
Ctrl+Alt+O = Output Window
Ctrl+- = NavigateBackward
Ctrl+Shift+- = NavigateForward
Ctrl + W = Select Current Word
Ctrl+R, Ctrl+W = View Whitespace
Ctrl + PgUp = View Top
Ctrl + PgDwn = View Down
Ctrl + Shft + N = New Project
Ctrl + Shft + O = Open Project
MSDN Help short cuts
Ctrl + Alt + F1 = View Contents Tab
Ctrl + Alt + F2 = View Index Tab
Ctrl + Alt + F3 = View Search Tab
Ctrl + Alt + F = View Favorites Tab
Ctrl + Alt + L = View Solution Explorer
Ctrl + Shft + 1 = View Browse Next
Ctrl + Shft + 2 = View Browse Previous
Ctrl + F10 = Run to cursor
Ctrl + Shft + F10 = Set Next Statement
Ctrl + F9 = EnableBreakpoint
Ctrl + Shft + F9 = Clear All Breakpoints
Ctrl + Alt + C = Call Stack
Ctrl + Alt + V, L = Locals
Ctrl + I = Incremental Search Down
Ctrl + Shft + I = Incremental Search Up
Ctrl + D = Go to find Combobox
Ctrl + Shft + F = Find in Files
F5 = Start
Shift + F5 = Stop Debugging
Ctrl + F5 = Start Without Debugging
F11 = Step Into
Shift + F11 = Step Out
F10 = Step Over
Ctrl + Alt V, T = This
Ctrl + Alt + H = Threads
Shift + Alt + Down Arrow = Line Down Extend Column
Shift + Alt + Up Arrow = Line Up Extend Column
Ctrl + Shift + U = Make Uppercase (Great for those of you who capitalize constants)
Ctrl + U = Make Lowercase
Shift + Alt + F3 = Search results
Shift + Alt + F2 = Index results
Ctrl + Shift + C = Class View
Ctrl + Shift + E = Resource View
F4 = Properties Window
Shift + F4 = Property Pages
Ctrl + Alt + X = Toolbox
Ctrl+ Alt + K = Task List
Ctrl + Alt + D = Dissasembly
Ctrl + F11 = Toggle Dissasembly
Ctrl + Alt + E = Exceptions
Ctrl + Alt + S = Server Explorer